Chromatography in Pharmacy & Pharmaceutical

One of the most characteristic features of the development in the methodology of pharmaceutical and biomedical analysis is that HPLC became undoubtedly the most important analytical method for identification and quantification of drugs, either in their active pharmaceutical ingredient or in their formulations during the process of their discovery, development and manufacturing.

Drug development starts with the discovery of a molecule with a therapeutic value. This can be done by high throughput screening during which separations by fast or ultra-fast HPLC are performed. At the discovery stage there can be also characterizing synthetic or natural products. Drug metabolism and pharmacokinetics (DMPK) is the step where the candidate compounds for drug are tested for their metabolism and pharmacokinetics. The studies involve use of LC-MS or LC-MS/MS. The goal in the discovery stage of drug development is to discover a new, safe and active chemical entity (NCE) that will become medication for diseases. During the last decade parallel synthesis of potential lead compounds, using combinatorial chemistry has been done. Due to its high sensitivity and selectivity, HPLC coupled with tandem mass spectrometry, HPLC-MS/MS has become the predominant method in bioassays, and pharmacokinetic and metabolic studies.

Chromatography and spectroscopy are orthogonal techniques, i.e. their types of information are very different and are specific. Chromatography is a separation method and spectroscopy is a technique which yields a ‘fingerprint’ of individual or from mixture of molecules. HPLC is a technique for separation, quantification and identification of components in a mixture. It is especially suitable for compounds which are not easily volatilized, thermally unstable and have high molecular weights. The advantage of UV method over HPLC method is that the UV method does not require the elaborate treatment and procedures usually associated with chromatographic method. It is less time consuming and economical. The HPLC and UV spectrometry methods are adequate methods to quantify a drug in pure form and its dosage form. Since these methods are simple, specific, rapid, precise and accurate, they may be successfully and conveniently adopted for routine quality control analysis of drugs in bulk and pharmaceutical dosage form.

  • Assay & Content Uniformity
  • Drug Impurities Analysis
  • Drug Discovery & Drug Development
  • Method Development & Validation of Drugs

Related Conference of Chromatography in Pharmacy & Pharmaceutical

May 27- 28, 2019

13th International Conference on Electrochemistry

Barcelona, Spain
June 10-11, 2019

14th World Congress on Medicinal Chemistry and Drug Design

Edinburgh, Scotland
June 10-11, 2019

8th World Congress on Mass Spectrometry

Edinburgh, Scotland
June 17-18, 2019

9th European Chemistry Congress

| Golden Tulip Berlin- Hotel Hamburg | Berlin, Germany
July 10-11, 2019

10th World Congress on Green Chemistry and Technology

Paris, France | HOLIDAY INN PARIS - PORTE DE CLICHY
August 08-09, 2019

6th International Conference on Organic and Inorganic Chemistry

Amsterdam, Netherlands
August 12-13, 2019

2nd World Congress on Petrochemistry

Auckland, NewZealand
September 02-03, 2019

6th International Conference on Physical and Theoretical Chemistry

Zurich, Switzerland
October 10-11, 2019

11th World Congress on Chemistry

Dubrovnik, Croatia
October 23-24, 2019

6th International Conference on Physical and Theoretical Chemistry

Amsterdam, Netherlands
October 24-25, 2019

10th World Congress on Mass Spectrometry & Analytical Techniques

Prague | Czech Republic
October 30-31, 2019

26th World Congress on Chemistry

London, UK
November 18-19, 2019

10th World Meet on Analytical Chemistry & Instrumentation

Bangkok, Thailand
November 18-19, 2019

8th Global Conference on Mass Spectrometry

Osaka, Japan
November 18-19, 2019

World Polymer Chemistry & Biopolymers Congress

Rome, Italy
March 18-19, 2020

11th European Organic Chemistry Congress

London, UK

Chromatography in Pharmacy & Pharmaceutical Conference Speakers

Recommended Sessions

Related Journals

Are you interested in