Dalia Alaa El-Din Aly El-Waseef
Ain Shams University, Egypt.
Title: The Histological Changes in Rat’s Brain with Alcohol are Potentially Due to Activation of Cerebral NLRP3 Inflammasomes
Biography
Biography: Dalia Alaa El-Din Aly El-Waseef
Abstract
BACKGROUND: Chronic alcoholism is associated with impaired cognitive function and remarkable histological changes.
AIM OF THE WORK: To demonstrate whether the histological changes associated with chronic alcohol ingestion are due to activation of Cerebral NLRP3 Inflammasomes by miRNA155 or not.
MATERIALS AND METHODS: Sixteen male Wistar rats were used. They were divided into 2 groups. Group I; the control naïve group, group II; chronic alcohol ingestion (10g/kg/day). Brain biochemical and histological studies were done. RESULTS: Alcohol induced cognitive impairment with increasing the expression of miRNA155, NLRP3, IL-1β and caspase-8 immune-reaction. CONCLUSIONS: alcohol could aggravate cognitive dysfunction via targeting NLRP3 inflammasomes pathway and its epigenetic regulator miRNA155.
CONCLUSIONS: MiRNA155 could be a molecular marker and therapeutic target in alcohol dependent patients for early detection and prevention of cognitive dysfunction.
Key Words; Alcohol; miRNA155; NLRP3 inflammasomes; Caspase-8; IL-I β; Frontal lobe.