Madhuri Singhal
Government M V M College, India
Title: Role of chromatographic techniques for drug discovery and development
Biography
Biography: Madhuri Singhal
Abstract
Chromatographic techniques are extensively used for isolation and separation of bioactive constituents present in different plants having medicinal value. Plant extracts after cold and hot extraction process were subjected to column chromatography for the separation of different bands corresponding to class of compounds using different solvents in various proportions. Portions having sufficient compound, after evaporation are separated to a single compound by using thin layer chromatography. In her research work author has isolated novel isoflavone glycoside, prenylated flavone glycoside and novel triterpenoidal saponin from the plant Pithecellobium dulce. She has also isolated different compounds from plants Terminalia bellerica, Moringa oleifera and other indigenous medicinal plants. The extract of Terminalia bellerica was found to possess anticancer activity while the extract of plant Moringa oleifera was found to have anti-diabetic activity. The application of chromatography technique on natural products is quite useful in order to form herbal based drug with no side effects and toxicity.